Type

Journal Article

Authors

Eamon Dolan
Sandra Luitjens
Joseph Galvin
Andreas Jerrentrup
Benjamin Scott
Sofie Brouwers
Danny Schoors
John Faul

Subjects

Medicine & Nursing

Topics
humans physiopathology treatment outcome surgery female diagnosis vascular resistance iliac vein blood iliac artery male aged middle aged instrumentation hypertension time factors vasodilation europe blood pressure cardiac output complications oxygen arteriovenous shunt surgical pulmonary circulation pulmonary disease chronic obstructive

Creation of an iliac arteriovenous shunt lowers blood pressure in chronic obstructive pulmonary disease patients with hypertension. (2013)

Abstract Vasodilators are used with caution in patients with chronic obstructive pulmonary disease (COPD). We have developed a device for percutaneous arteriovenous shunt creation in the iliac region to increase cardiac output and oxygen delivery for patients with COPD. Although this device does not cause significant blood pressure changes in normotensive patients with COPD, we hypothesized that arteriovenous shunt creation might cause vasodilator effects in hypertensive patients because of a reduction in vascular resistance. Twenty-four patients with COPD and hypertension enrolled in an open label study of arteriovenous shunt creation for COPD. We performed cardiac catheterization at baseline and again 3 to 6 months after the procedure. As a safety measure we also recorded office blood pressure at baseline and again after 3, 6, 9, and 12 months. The procedure increased oxygen delivery (1.1-1.4 L.min(-1)) and cardiac output (6-8.2 L.min(-1)) (P < .001) and lowered both the systemic vascular resistance (P < .001) and the pulmonary vascular resistance (P < .01). After 12 months, however, the average systolic blood pressure was reduced from 145 to 132 mm Hg (P < .0001), and the average diastolic blood pressure was reduced from 86 to 67 mm Hg (P < .0001). Percutaneous iliac arteriovenous fistula creation for COPD causes a significant and persistent lowering of blood pressure in patients with co-existing hypertension.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Eamon Dolan, Sandra Luitjens, Joseph Galvin, Andreas Jerrentrup, Benjamin Scott, Sofie Brouwers, Danny Schoors, John Faul

Experts in our system

1
Eamon Dolan
IT Blanchardstown
Total Publications: 42
 
2
Benjamin Scott
Royal College of Surgeons in Ireland
Total Publications: 4
 
3
Danny Schoors
Royal College of Surgeons in Ireland
Total Publications: 4
 
4
John Faul
IT Blanchardstown
Total Publications: 11