Type

Journal Article

Authors

John H McDermott
Fergal D Malone
Seamus Sreenan
Noel G McElvaney
Patrick Dicker
Emer P Reeves
Fiona Manning
Etaoin M Kent
David A Bergin
Thomas F J King

Subjects

Medicine & Nursing

Topics
low birthweight endothelial cells gestational age blood pressure cardiovascular risk prospective cohort study progenitor cells maternal mortality

Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk? (2012)

Abstract Offspring birthweight is inversely associated with future maternal cardiovascular mortality, a relationship that has yet to be fully elucidated. Endothelial progenitor cells (EPCs) are thought to play a key role in vasculogenesis, and EPC numbers reflect cardiovascular risk. Our objective was to ascertain whether EPC number or function was reduced in mothers of low-birthweight infants. This was a prospective cohort study in a general antenatal department of a university maternity hospital. Twenty-three mothers of small for gestational age (SGA) infants (birthweight < 10th centile) and 23 mothers of appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile) were recruited. Maternal EPC number and function, conventional cardiovascular risk markers, and cord blood adiponectin were measured. Median EPC count was lower (294 vs. 367, P = 0.005) and EPC migration was reduced (0.91 vs. 1.59, P < 0.001) in SGA compared with AGA infants, with no difference in EPC adhesion (0.221 vs. 0.284 fluorescence units, P = 0.257). Maternal triglyceride levels were higher in SGA than AGA infants (0.98 vs. 0.78 mmol/liter, P = 0.006), but there was no difference in cholesterol, glucose, insulin, glycosylated hemoglobin, adiponectin, or blood pressure. There was a moderate monotone (increasing) relationship between birthweight and umbilical cord blood adiponectin (r = 0.475, P = 0.005). Giving birth to an SGA infant was associated with lower maternal EPC number and reduced migratory function. Cord blood adiponectin was significantly correlated with birthweight.
Collections Ireland -> TU Dublin (Blanchardstown Campus) -> PubMed

Full list of authors on original publication

John H McDermott, Fergal D Malone, Seamus Sreenan, Noel G McElvaney, Patrick Dicker, Emer P Reeves, Fiona Manning, Etaoin M Kent, David A Bergin, Thomas F J King

Experts in our system

1
J H McDermott
TU Dublin (Blanchardstown Campus)
Total Publications: 14
 
2
Fergal D Malone
Royal College of Surgeons in Ireland
Total Publications: 73
 
3
Seamus Sreenan
TU Dublin (Blanchardstown Campus)
Total Publications: 36
 
4
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
5
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
 
6
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
7
Etaoin Kent
Royal College of Surgeons in Ireland
Total Publications: 10
 
8
David A Bergin
Royal College of Surgeons in Ireland
Total Publications: 28