Type

Journal Article

Authors

Richard W Costello
Carsten Ehrhardt
Gloria Crispino-O'Connell
Richard B Reilly
Emer Reeves
David Bergin
Martin S Holmes
Shona D'Arcy
Elaine MacHale
Imran Sulaiman
and 6 others

Subjects

Pharmacology

Topics
drug delivery systems acoustics instrumentation physiology sensitivity analysis equipment design fluticasone propionate salmeterol xinafoate drug combination drug delivery albuterol drug development and evaluation analogs derivatives delivery aerosol aerosols administration inhalation inhalation humans inspiratory capacity acoustic androstadienes dry powder inhalers blood drug combinations administration dosage pharmacokinetics

The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus¿ dry powder inhaler. (2014)

Abstract Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of an inhalation are related to the PIFR and hence reflect drug delivery. METHODS: A sensitivity analysis of the relationship of the acoustics of inhalation to simultaneously recorded airflow, in a cohort of volunteers (n = 92) was performed. The Next Generation Impactor (NGI) was used to assess in vitro drug delivery from salmeterol/fluticasone and salbutamol Diskus™ DPIs. Fine particle fraction, FPF, (<5 μm) was measured at 30-90 l/min for 2-6 s and correlated with acoustically determined flow rate (IFRc). In pharmacokinetic studies using a salbutamol (200 μg) Diskus™, volunteers inhaled either at maximal or minimal effort on separate days. RESULTS: PIFRc was correlated with spirometrically determined values (R (2) = 0.88). In in vitro studies, FPF increased as both flow rate and inhalation duration increased for the salmeterol/fluticasone Diskus™ (Adjusted R (2) = 0.95) and was proportional to flow rate only for the salbutamol Diskus™ (Adjusted R (2) = 0.71). In pharmacokinetic studies, blood salbutamol levels measured at 20 min were significantly lower when PIFRc was less than 60 l/min, p < 0.0001. CONCLUSION: Acoustically-determined PIFR is a suitable method for estimating drug delivery and for monitoring inhalation technique over time.
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Full list of authors on original publication

Richard W Costello, Carsten Ehrhardt, Gloria Crispino-O'Connell, Richard B Reilly, Emer Reeves, David Bergin, Martin S Holmes, Shona D'Arcy, Elaine MacHale, Imran Sulaiman and 6 others

Experts in our system

1
Richard W Costello
Royal College of Surgeons in Ireland
Total Publications: 66
 
2
Carsten Ehrhardt
Trinity College Dublin
Total Publications: 71
 
3
Richard Reilly
Trinity College Dublin
Total Publications: 185
 
4
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 58
 
5
David A Bergin
Royal College of Surgeons in Ireland
Total Publications: 27
 
6
Martin S Holmes
Royal College of Surgeons in Ireland
Total Publications: 13
 
7
Shona D'Arcy
Royal College of Surgeons in Ireland
Total Publications: 19
 
8
Elaine MacHale
Royal College of Surgeons in Ireland
Total Publications: 19
 
9
Imran Sulaiman
Royal College of Surgeons in Ireland
Total Publications: 24