Journal Article


D J Bouchier-Hayes
T N Walsh
M Moriarty
D Foley
M E Sheridan
G Holden
C O McDonnell



antineoplastic agents carcinoma lewis lung neoplasm transplantation antimetabolites antineoplastic fluorouracil injections intraperitoneal treatment outcome therapeutic use blood vessels chemotherapy adjuvant radiotherapy adjuvant mice inbred c57bl microcirculation drug therapy vascular endothelial growth factor a blood pathology antineoplastic combined chemotherapy protocols angiogenesis inhibitors administration dosage animals cisplatin radiotherapy genistein mice drug effects

Improvement in efficacy of chemoradiotherapy by addition of an antiangiogenic agent in a murine tumor model. (2004)

Abstract Chemoradiotherapy improves survival for some cancer patients. Methods of enhancing treatment response would further enhance survival rates. The effect of the addition of an antiangiogenic agent to a chemoradiotherapy regime has not previously been examined. C57B16 mice were inoculated with 1 x 10(6) Lewis lung carcinoma cells into the flank and randomized to 1 of 10 treatment groups when tumor volume approached 1000 mm(3). Animals received combinations of standard doses of intraperitoneal cisplatin, 5-fluorouracil, and the antiangiogenic agent genistein, together with 10 or 20 Gy of external beam radiotherapy. Animals were sacrificed at day 6 when tumor volume, microvessel density, and serum VEGF were determined. Mean (SEM) tumor volume in the chemoradiotherapy group was 762 (212) mm(3) versus 565 (79) mm(3) in the chemoradiotherapy plus genistein group (P = 0.04, unpaired t-test). The addition of genistein produced a significant reduction in tumor microvessel density (P = 0.01) as well as serum VEGF levels (P < 0.05) compared to those animals receiving chemoradiation alone. This study provides proof of principle that chemoradiation can be enhanced by the addition of an antiangiogenic agent to the regime and suggests that further examination of such regimes is warranted.
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Full list of authors on original publication

D J Bouchier-Hayes, T N Walsh, M Moriarty, D Foley, M E Sheridan, G Holden, C O McDonnell

Experts in our system

T N Walsh
IT Blanchardstown
Total Publications: 53