Type

Journal Article

Authors

Eleanor J Molloy
Malachi J McKenna
Nuala Murphy
Mark Kilbane
Ricardo Segurado
Heike Bruell
Dermot Doherty
Aoife Carroll
Chike Onwuneme

Subjects

Medicine & Nursing

Topics
mechanical ventilation paediatric outcomes children sepsis vitamin d intensive care culture

Inadequate vitamin D levels are associated with culture positive sepsis and poor outcomes in paediatric intensive care. (2014)

Abstract This study aimed to assess vitamin D status, and its determinants, in paediatric patients with suspected sepsis who were admitted to a paediatric intensive care unit (PICU). We also investigated the association between vitamin D status and clinical outcomes. Serum 25-hydroxy vitamin D (25OHD) and clinical determinants were prospectively assessed in children with suspected sepsis (<12 years old) admitted to the PICU. The relationship between 25OHD and clinical outcomes was evaluated. Vitamin D status was also assessed in control children of a similar age. We enrolled 120 children with suspected sepsis admitted to the PICU and 30 paediatric controls. 25OHD was <50 nmol/L in 59% of the children admitted to the PICU and 25OHD was lower than in the controls (47 ± 29 vs 66 ± 26 nmol/L, p < 0.001). After adjusting for potential confounders, 25OHD was strongly associated with culture positive sepsis (p < 0.001), the paediatric index of mortality (p = 0.026) and the duration of mechanical ventilation (p = 0.008). There was a negative correlation between 25OHD and C-reactive protein (CRP): each 0.1% decrease in 25OHD increased CRP (p = 0.04). Children admitted to the PICU with suspected sepsis had lower 25OHD than controls and inadequate 25OHD status was associated with confirmed sepsis and poor outcomes.
Collections Ireland -> TU Dublin (Tallaght Campus) -> PubMed

Full list of authors on original publication

Eleanor J Molloy, Malachi J McKenna, Nuala Murphy, Mark Kilbane, Ricardo Segurado, Heike Bruell, Dermot Doherty, Aoife Carroll, Chike Onwuneme

Experts in our system

1
Eleanor J Molloy
TU Dublin (Tallaght Campus)
Total Publications: 22
 
2
Malachi J McKenna
University College Dublin
Total Publications: 19
 
3
Nuala Murphy
University College Dublin
Total Publications: 15
 
4
Mark Kilbane
University College Dublin
Total Publications: 10
 
5
Ricardo Segurado
University College Dublin
Total Publications: 64
 
6
Chike Onwuneme
TU Dublin (Tallaght Campus)
Total Publications: 6