Journal Article


Colm A O'Moráin
Deirdre McNamara
Anthony O'Connor


Medicine & Nursing

precancerous conditions stomach neoplasms prevention control stomach metaplasia diagnosis humans pathology adenocarcinoma

Surveillance of gastric intestinal metaplasia for the prevention of gastric cancer. (2013)

Abstract Adenocarcinoma of the stomach is the second leading cause of cancer related death in the world. Gastric intestinal metaplasia (GIM) is a recognised premalignant condition of the stomach. It has been described as occurring in up to one in five patients in western countries. Although there is a definite risk of progression from GIM to cancer, published guidelines and statements differ as to the utility and structure of surveillance programs for this condition. To see whether or not endoscopic or biochemical surveillance of patients with gastric intestinal metaplasia (GIM) could result in increased detection of dysplasia and early gastric cancer to decrease gastric cancer mortality. We performed a search of the following electronic databases from inception to October 2012: CENTRAL, EMBASE, MEDLINE and LILACS. We handsearched for abstracts from relevant conferences. Randomised controlled trials only were included. No studies met the inclusion criteria. No studies met the inclusion criteria. There is a lack of randomised data on the utility of surveillance of GIM. The observational data from non-randomised studies are discussed and would suggest that although a randomised trial would be a desirable undertaking to attain the highest grade of clinical evidence, given the ethical and acceptability issues involved, further non-randomised clinical studies focussing on surveillance protocols and the role of Helicobacter pylori eradication may be a more pragmatic means of addressing the core clinical question.
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Full list of authors on original publication

Colm A O'Moráin, Deirdre McNamara, Anthony O'Connor

Experts in our system

Deirdre McNamara
TU Dublin (Tallaght Campus)
Total Publications: 51
Anthony O'Connor
TU Dublin (Tallaght Campus)
Total Publications: 20