Journal Article


C O'Morain
P Murphy
D McNamara
H O'Connor
N Breslin
B Ryan
N Fitzgerald
A Nami
I Taneike
A O'Connor



rifabutin centre tetracycline resistance therapy united kingdom irish helicobacter pylori reference

Helicobacter pylori resistance rates for levofloxacin, tetracycline and rifabutin among Irish isolates at a reference centre. (2012)

Abstract INTRODUCTION: Helicobacter pylori eradication rates using conventional triple therapies are falling, making viable second-line and rescue regimens necessary. Levofloxacin, tetracycline and rifabutin are three efficacious antibiotics for rescue therapy. AIM: We aimed to assess the resistance rates for H. pylori against these antibiotics in an Irish cohort. METHODS: Gastric biopsies were collected from 85 patients infected with H. pylori (mean age 46 years) in the Adelaide and Meath Hospital, Dublin in 2008 and 2009. Susceptibility to antibiotics was tested using the Etest. Clinical information was obtained from endoscopy reports and chart review. RESULTS: 50.6 % of patients were females. Mean age was 47 years. Ten had prior attempts at eradication therapy with amoxicillin-clarithromycin-PPI, two had levofloxacin-based second-line therapy. 11.7 % [95 % CI (6.5-20.3 %)] (N = 10) had strains resistant to levofloxacin. There were no strains resistant to rifabutin or tetracycline. Levofloxacin resistance in the under 45 age group was 2.6 % (1/38) compared to 19.1 % (9/47) of above 45 age group (p = 0.02). DISCUSSION: The levofloxacin rates illustrated in this study are relatively low by European standards and in line with other studies from the United Kingdom and Germany, with younger patients having very low levels of resistance. Levofloxacin, tetracycline and rifabutin are all valid options for H. pylori eradication in Irish patients but the importance of compliance cannot be underestimated.
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Full list of authors on original publication

C O'Morain, P Murphy, D McNamara, H O'Connor, N Breslin, B Ryan, N Fitzgerald, A Nami, I Taneike, A O'Connor

Experts in our system

Colm O'Morain
TU Dublin (Tallaght Campus)
Total Publications: 82
Paul V Murphy
National University of Ireland Galway
Total Publications: 73
Deirdre McNamara
TU Dublin (Tallaght Campus)
Total Publications: 51
H J O'Connor
TU Dublin (Tallaght Campus)
Total Publications: 28
N Breslin
Trinity College Dublin
Total Publications: 12
B Ryan
TU Dublin (Tallaght Campus)
Total Publications: 28
Anthony O'Connor
TU Dublin (Tallaght Campus)
Total Publications: 20