Type

Journal Article

Authors

Sean O'Riordan
Richard Walsh
Laura Williams
Tim Lynch
Okka Kimmich
John Butler
Anna Molloy
Daniel G Healy
Cathal Walsh
Tadashi Isa
and 4 others

Subjects

Psychiatry

Topics
dystonia covert attention gamma aminobutyric acid experimental superior colliculus network temporal neurons temporal discrimination disorder cervical dystonia gaba substantia nigra

Cervical dystonia: a disorder of the midbrain network for covert attentional orienting. (2014)

Abstract While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid (GABA) inhibition, resulting, in turn, from as yet undetermined, genetic mutations. Such disinhibition is (a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus and (b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective GABA activity both within the superior colliculus and from the substantia nigra pars reticulata. A number of experiments are required to prove or disprove this hypothesis.
Collections Ireland -> University College Dublin -> School of Medicine
Ireland -> University of Limerick -> Mathematics & Statistics
Ireland -> Trinity College Dublin -> Administrative Staff Authors (Scholarly Publications)
Ireland -> Trinity College Dublin -> Administrative Staff Authors
Ireland -> University of Limerick -> Faculty of Science and Engineering
Ireland -> University College Dublin -> College of Health and Agricultural Sciences
Ireland -> University of Limerick -> Departments Science and Engineering
Ireland -> University College Dublin -> Medicine Research Collection

Full list of authors on original publication

Sean O'Riordan, Richard Walsh, Laura Williams, Tim Lynch, Okka Kimmich, John Butler, Anna Molloy, Daniel G Healy, Cathal Walsh, Tadashi Isa and 4 others

Experts in our system

1
Sean O'Riordan
Trinity College Dublin
Total Publications: 20
 
2
Richard Walsh
University of Limerick
Total Publications: 5
 
3
Laura Williams
Trinity College Dublin
Total Publications: 13
 
4
Tim Lynch
University College Dublin
Total Publications: 12
 
5
Okka Kimmich
Trinity College Dublin
Total Publications: 8
 
6
John S Butler
Trinity College Dublin
Total Publications: 27
 
7
Anna Molloy
Trinity College Dublin
Total Publications: 8
 
8
Daniel G Healy
University College Dublin
Total Publications: 4
 
9
Cathal Walsh
Trinity College Dublin
Total Publications: 94