Type

Journal Article

Authors

Richard W Costello
Isabelle Killane
Frank Keane
Terence Taylor
John McCourt
Thekra Al-Zaabi
Senan Glynn
Conor O'Reilly
Deirdre Hyland
Imran Sulaiman
and 6 others

Subjects

Music

Topics
time factors patient compliance adherence recordings inhalation adult nebulizers and vaporizers aged 80 and over humans adolescent energy acoustic female individual technology automatic data processing training medicine and health sciences male acoustics young adult inhaler 80 and over aged middle aged

A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events (2014)

Abstract Rationale Poor adherence to inhaler use can be due to poor temporal and/or technique adherence. Up until now there has been no way of reliably tracking both these factors in everyday inhaler use. Objectives This paper introduces a device developed to create time stamped acoustic recordings of an individual's inhaler use, in which empirical evidence of temporal and technique adherence in inhaler use can be monitored over time. The correlation between clinical outcomes and adherence, as determined by this device, was compared for temporal adherence alone and combined temporal and technique adherence. Findings The technology was validated by showing that the doses taken matched the number of audio recordings (r2 = 0.94, p<0.01). To demonstrate that audio analysis of inhaler use gives objective information, in vitro studies were performed. These showed that acoustic profiles of inhalations correlated with the peak inspiratory flow rate (r2 = 0.97, p<0.01), and that the acoustic energy of exhalations into the inhaler was related to the amount of drug removed. Despite training, 16% of participants exhaled into the mouthpiece after priming, in >20% of their inhaler events. Repeated training reduced this to 7% of participants (p = 0.03). When time of use was considered, there was no evidence of a relationship between adherence and changes in AQLQ (r2 = 0.2) or PEFR (r2 = 0.2). Combining time and technique the rate of adherence was related to changes in AQLQ (r2 = 0.53, p = 0.01) and PEFR (r2 = 0.29, p = 0.01). Conclusions This study presents a novel method to objectively assess how errors in both time and technique of inhaler use impact on clinical outcomes.
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Full list of authors on original publication

Richard W Costello, Isabelle Killane, Frank Keane, Terence Taylor, John McCourt, Thekra Al-Zaabi, Senan Glynn, Conor O'Reilly, Deirdre Hyland, Imran Sulaiman and 6 others

Experts in our system

1
Richard W Costello
Royal College of Surgeons in Ireland
Total Publications: 62
 
2
Isabelle Killane
Royal College of Surgeons in Ireland
 
3
F B V Keane
IT Tallaght
Total Publications: 25
 
4
Terence E Taylor
Royal College of Surgeons in Ireland
 
5
Imran Sulaiman
Royal College of Surgeons in Ireland
Total Publications: 24