Type

Journal Article

Authors

Gary Donohoe
Aiden P Corvin
Michael Gill
Erik O'Hanlon
Carol O'Brien
Ciara Fahey
Emma Jane Rose
Omar Mothersill
Derek W Morris
Sinead Kelly

Subjects

Psychiatry

Topics
mirn137 microrna human variant polymorphism single nucleotide aged male adult young adult pathology anatomy histology humans middle aged schizophrenia adolescent microstructure white matter genome human micrornas female genotype genetics diffusion tensor imaging genetic association studies genome

Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants. (2014)

Abstract A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ). However, the mechanisms by which SZ risk may be mediated by this variant are unknown. As miRNAs have the potential to influence oligodendrocyte development, we investigated whether this SNP was associated with variability in white matter (WM) microstructure. Diffusion tensor imaging (DTI) was conducted on 123 healthy participants genotyped for rs1625579. The analysis consisted of whole-brain tract-based spatial statistics and atlas-based tractography analysis of six major WM tracts known to be affected in SZ - the inferior longitudinal fasciculus, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the anterior thalamic radiation, the cingulum bundle and the corpus callosum. No significant differences in either whole-brain fractional anisotropy or mean diffusivity between MIR137 genotype groups were observed (p>0.05). Similarly, atlas-based tractography of particular tracts implicated in SZ failed to reveal any significant differences between MIR137 genotype groups on measures of WM connectivity (p>0.05). In the absence of WM effects comparable to those reported for other SZ associated genes, these data suggest that MIR137 alone may not confer variability in these WM measures and therefore may not act in isolation for any effects that the variant may have on WM microstructure in SZ samples.
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Full list of authors on original publication

Gary Donohoe, Aiden P Corvin, Michael Gill, Erik O'Hanlon, Carol O'Brien, Ciara Fahey, Emma Jane Rose, Omar Mothersill, Derek W Morris, Sinead Kelly

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Erik O'Hanlon
Trinity College Dublin
Total Publications: 15
 
5
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
6
Emma Jane Rose
Trinity College Dublin
Total Publications: 19
 
7
Omar Mothersill
National University of Ireland Galway
Total Publications: 14
 
8
Derek Morris
Trinity College Dublin
Total Publications: 150
 
9
Sinead Kelly
Trinity College Dublin
Total Publications: 16