Type

Journal Article

Authors

Padraic G Fallon
Mario A Fares
Paul N Moynagh
Gemma K Kinsella
Brian E Caffrey
Christopher D Cluxton

Subjects

Biochemistry

Topics
toll like receptor immune system diseases drosophila melanogaster ancestral protein helminth proteins immunology inflammation infection children s research pellino protein medical pharmacology human cells protein tyrosine kinases medical genetics schistosoma mansoni immune system free living organisms helminth species transforming growth factor beta ubiquitin conjugating enzymes mitogen activated protein kinase

Functional conservation of an ancestral Pellino protein in helminth species. (2015)

Abstract The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as Drosophila melanogaster. The TLR pathway is ubiquitous and controls sensitivity to pathogen-associated molecular patterns (PAMPs) in eukaryotes. There is, however, a marked absence of this pathway from the plathyhelminthes, with the exception of the Pellino protein family, which is present in a number of species from this phylum. Helminth Pellino proteins are conserved having high similarity, both at the sequence and predicted structural protein level, with that of human Pellino proteins. Pellino from a model helminth, Schistosoma mansoni Pellino (SmPellino), was shown to bind and poly-ubiquitinate human IRAK-1, displaying E3 ligase activity consistent with its human counterparts. When transfected into human cells SmPellino is functional, interacting with signaling proteins and modulating mammalian signaling pathways. Strict conservation of a protein family in species lacking its niche signalling pathway is rare and provides a platform to examine the ancestral functions of Pellino proteins that may translate into novel mechanisms of immune regulation in humans.
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Full list of authors on original publication

Padraic G Fallon, Mario A Fares, Paul N Moynagh, Gemma K Kinsella, Brian E Caffrey, Christopher D Cluxton

Experts in our system

1
Padraic Fallon
Trinity College Dublin
Total Publications: 145
 
2
Mario Ali Fares
Trinity College Dublin
Total Publications: 43
 
3
Paul N Moynagh
Maynooth University
Total Publications: 79
 
4
Gemma K Kinsella
Maynooth University
Total Publications: 4
 
5
Brian E Caffrey
Trinity College Dublin
Total Publications: 4
 
6
Christopher D Cluxton
Trinity College Dublin
Total Publications: 3