Type

Journal Article

Authors

Fiona Walsh
Colin Hill
Paul D. Cotter
Catherine Stanton
Fiona Fouhy

Subjects

Microbiology

Topics
antimicrobial resistance metagenomics this review proteins functional proteomics dna natural products bacteria

Proteomics as the final step in the functional metagenomics study of antimicrobial resistance. (2014)

Abstract The majority of clinically applied antimicrobial agents are derived from natural products generated by soil microorganisms and therefore resistance is likely to be ubiquitous in such environments. This is supported by the fact that numerous clinically important resistance mechanisms are encoded within the genomes of such bacteria. Advances in genomic sequencing have enabled the in silico identification of putative resistance genes present in these microorganisms. However, it is not sufficient to rely on the identification of putative resistance genes, we must also determine if the resultant proteins confer a resistant phenotype. This will require an analysis pipeline that extends from the extraction of environmental DNA, to the identification and analysis of potential resistance genes and their resultant proteins and phenotypes. This review focuses on the application of functional metagenomics and proteomics to study antimicrobial resistance in diverse environments.
Collections Ireland -> Maynooth University -> PubMed

Full list of authors on original publication

Fiona Walsh, Colin Hill, Paul D. Cotter, Catherine Stanton, Fiona Fouhy

Experts in our system

1
Fiona Walsh
Maynooth University
Total Publications: 25
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Paul D. Cotter
Teagasc
Total Publications: 253
 
4
Catherine Stanton
Teagasc
Total Publications: 261
 
5
Fiona Fouhy
Teagasc
Total Publications: 27