Journal Article


Mario A Fares
Christina Toft



computational biology models statistical genomics models genetic software animals genome bacterial aphids genome evolution molecular databases genetic multigene family algorithms

GRAST: a new way of genome reduction analysis using comparative genomics. (2006)

Abstract MOTIVATION: Establishment of intra-cellular life involved a profound re-configuration of the genetic characteristics of bacteria, including genome reduction and rearrangements. Understanding the mechanisms underlying these phenomena will shed light on the genome rearrangements essential for the development of an intra-cellular lifestyle. Comparison of genomes with differences in their sizes poses statistical as well as computational problems. Little efforts have been made to develop flexible computational tools with which to analyse genome reduction and rearrangements. RESULTS: Investigation of genome reduction and rearrangements in endosymbionts using a novel computational tool (GRAST) identified gathering of genes with similar functions. Conserved clusters of functionally related genes (CGSCs) were detected. Heterogeneous gene and gene cluster non-functionalization/loss are identified between genome regions, functional gene categories and during evolution. Results show that gene non-functionalisation has accelerated during the last 50 MY of Buchnera's evolution while CGSCs have been static.
Collections Ireland -> Maynooth University -> PubMed

Full list of authors on original publication

Mario A Fares, Christina Toft

Experts in our system

Mario Ali Fares
Trinity College Dublin
Total Publications: 43
Christina Toft
Trinity College Dublin
Total Publications: 6