Type

Journal Article

Authors

Martin Clynes
Robert O'Connor
Paula Kinsella
Vickie McKee
Michael Devereux
Kevin Kavanagh
Paul McCormack
Sinead McKay
Barry Coyle
Malachy McCann

Subjects

Microbiology

Topics
pharmacology metals phenanthrolines cytokinesis animals mammalian cells cells cultured protein conformation 10 phenanthroline microscopy electron copper ii perchlorate x ray crystal structure cell division x rays antineoplastic agents metabolism copper humans models chemical crystallography x ray chemistry chemical synthesis cell line tumor perchloric acid 2 ag dna fungal fungal proteins 1 10 phenanthroline 5 6 dione candida albicans anti cancer

Synthesis and X-ray crystal structure of [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione) and its effects on fungal and mammalian cells. (2004)

Abstract The Cu(II) and Ag(I) complexes, [Cu(phendio)3](ClO4)2 x 4H2O and [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione), are prepared in good yield by reacting phendio with the appropriate metal perchlorate salt. The X-ray crystal structure of the Ag(I) complex shows it to have a pseudo tetrahedral structure. 'Metal-free' phendio and the Cu(II) and Ag(I) phendio complexes strongly inhibit the growth of the fungal pathogen Candida albicans, and are more active than their 1,10-phenanthroline analogues. The simple Ag(I) salts, AgCH3CO2, AgNO3 and AgClO4 x H2O display superior anti-fungal properties compared to analogous simple Cu(II) and Mn(II) salts, suggesting that the nature of the metal ion strongly influences activity. Exposing C. albicans to 'metal-free' phendio, simple Ag(I) salts and [Ag(phendio)2]ClO4 causes extensive, non-specific DNA cleavage. 'Metal-free' phendio and [Ag(phendio)2]ClO4 induce gross distortions in fungal cell morphology and there is evidence for disruption of cell division. Both drugs also exhibit high anti-cancer activity when tested against cultured mammalian cells.
Collections Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Biology
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset
Ireland -> Maynooth University -> PubMed

Full list of authors on original publication

Martin Clynes, Robert O'Connor, Paula Kinsella, Vickie McKee, Michael Devereux, Kevin Kavanagh, Paul McCormack, Sinead McKay, Barry Coyle, Malachy McCann

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Robert O'Connor
Dublin City University
Total Publications: 71
 
3
Vickie McKee
Dublin City University
Total Publications: 30
 
4
Michael Devereux
Dublin Institute of Technology
Total Publications: 49
 
5
Kevin Kavanagh
Maynooth University
Total Publications: 139
 
6
Malachy McCann
Maynooth University
Total Publications: 62