Type

Journal Article

Authors

Clifford C Taggart
Sinéad Weldon
Noel G McElvaney
Catherine M Greene
Niamh McGarry

Subjects

Biochemistry

Topics
gene expression enzyme activation apoptosis binding sites myeloid cells tumor necrosis factor alpha u937 cells monocytes proteinase inhibitory proteins secretory cell line medicine and health sciences proteinase inhibitory proteins secretory anti inflammatory caspase 7 cell line tumor nf b caspase 3 tumor oxidation reduction humans

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity. (2015)

Abstract Secretory Leukocyte Protease Inhibitor (SLPI) is a serine protease inhibitor produced by epithelial and myeloid cells with anti-inflammatory properties. Research has shown that SLPI exerts its anti-inflammatory activity by directly binding to NF-κB DNA binding sites and, in so doing, prevents binding and subsequent transcription of proinflammatory gene expression. In the current study, we demonstrate that SLPI can inhibit TNF-α-induced apoptosis in U937 cells and peripheral blood monocytes. Specifically, SLPI inhibits TNF-α-induced caspase-3 activation and DNA degradation associated with apoptosis. We go on to show that this ability of SLPI to inhibit apoptosis is not dependent on its antiprotease activity as antiprotease deficient variants of SLPI can also inhibit TNF-α-induced apoptosis. This reduction in monocyte apoptosis may preserve monocyte function during inflammation resolution and promote infection clearance at mucosal sites.
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Full list of authors on original publication

Clifford C Taggart, Sinéad Weldon, Noel G McElvaney, Catherine M Greene, Niamh McGarry

Experts in our system

1
Clifford C Taggart
Royal College of Surgeons in Ireland
Total Publications: 54
 
2
Sinéad Weldon
Royal College of Surgeons in Ireland
Total Publications: 9
 
3
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
4
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150