Type

Journal Article

Authors

Gianpiero L Cavalleri
Mary Fitzsimons
Norman Delanty
Colin P Doherty
Christopher D Whelan
Saud Alhusaini

Subjects

Psychiatry

Topics
epilepsy temporal lobe patients size cerebral cortex surface area morphology siblings entorhinal cortex

Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings. (2015)

Abstract Temporal cortex abnormalities are common in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE+HS) and believed to be relevant to the underlying mechanisms. In the present study, we set out to determine the familiarity of temporal cortex morphologic alterations in a cohort of MTLE+HS patients and their asymptomatic siblings. A surface-based morphometry (SBM) method was applied to process MRI data acquired from 140 individuals (50 patients with unilateral MTLE+HS, 50 asymptomatic siblings of patients, and 40 healthy controls). Using a region-of-interest approach, alterations in temporal cortex morphology were determined in patients and their asymptomatic siblings by comparing with the controls. Alterations in temporal cortex morphology were identified in MTLE+HS patients ipsilaterally within the anterio-medial regions, including the entorhinal cortex, parahippocampal gyrus, and temporal pole. Subtle but similar pattern of morphology changes with a medium effect size were also noted in the asymptomatic siblings. These localized alterations were related to volume loss that appeared driven by shared contractions in cerebral cortex surface area. These findings indicate that temporal cortex morphologic alterations are common to patients and their asymptomatic siblings and suggest that such localized traits are possibly heritable.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Gianpiero L Cavalleri, Mary Fitzsimons, Norman Delanty, Colin P Doherty, Christopher D Whelan, Saud Alhusaini

Experts in our system

1
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35
 
2
Mary Fitzsimons
Royal College of Surgeons in Ireland
Total Publications: 7
 
3
Norman Delanty
Royal College of Surgeons in Ireland
Total Publications: 41
 
4
Colin P Doherty
Trinity College Dublin
Total Publications: 35
 
5
Christopher D Whelan
Royal College of Surgeons in Ireland
Total Publications: 10
 
6
Saud Alhusaini
Royal College of Surgeons in Ireland
Total Publications: 10