Type

Journal Article

Authors

Fergal J O'Brien
Garry P Duffy
Sally-Ann Cryan
Kevin McSorley
Erica G Tierney
Caroline M Curtin

Subjects

Biochemistry

Topics
vegf scaffold bone regeneration stem cell cells collagen non viral gene delivery non viral gene therapy

Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold. (2014)

Abstract Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Fergal J O'Brien, Garry P Duffy, Sally-Ann Cryan, Kevin McSorley, Erica G Tierney, Caroline M Curtin

Experts in our system

1
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 265
 
2
Garry P Duffy
Royal College of Surgeons in Ireland
Total Publications: 54
 
3
Sally-Ann Cryan
Royal College of Surgeons in Ireland
Total Publications: 67
 
4
Kevin McSorley
Royal College of Surgeons in Ireland
Total Publications: 4
 
5
Erica G Tierney
Royal College of Surgeons in Ireland
Total Publications: 9
 
6
Caroline M Curtin
Royal College of Surgeons in Ireland
Total Publications: 22