Type

Journal Article

Authors

Noel G McElvaney
Kerstin Pohl
Kevin Molloy
Emer P Reeves

Subjects

Microbiology

Topics
mucus cystic fibrosis adolescent cystic fibrosis transmembrane conductance regulator lung diseases mutation drug therapy genetics metabolism elasticity infant newborn respiratory system physiology inflammation child pharmacology mucociliary clearance complications animals child preschool cftr protein human infection lung infant drug effects anti infective agents saline solution hypertonic humans

Hypertonic saline in treatment of pulmonary disease in cystic fibrosis. (2012)

Abstract The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans. Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airways. However, recent clinical and bench-top studies are beginning to broaden our view on the beneficial effects of hypertonic saline, which now extend to include anti-infective as well as anti-inflammatory properties. This review aims to discuss the described therapeutic benefits of hypertonic saline and specifically to identify novel models of hypertonic saline action independent of airway hydration.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Noel G McElvaney, Kerstin Pohl, Kevin Molloy, Emer P Reeves

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
Kerstin Pohl
Royal College of Surgeons in Ireland
 
3
Kevin Molloy
Royal College of Surgeons in Ireland
Total Publications: 19
 
4
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63