Type

Journal Article

Authors

Gianpiero L Cavalleri
Mary Fitzsimons
Norman Delanty
Paul Brennan
Sinead Maguire
Cathy Scanlon
Lena Palaniyappan
Colin P Doherty
Saud Alhusaini

Subjects

Psychiatry

Topics
male pathology functional laterality statistics nonparametric sclerosis middle aged adult magnetic resonance imaging brain mapping humans physiology electroencephalography epilepsy temporal lobe cerebral cortex image processing computer assisted female hippocampus complications

Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis. (2012)

Abstract To date, magnetic resonance imaging (MRI)-based studies of the cerebral cortex in mesial temporal lobe epilepsy (MTLE) have focused primarily on investigating cortical volume and thickness. However, volume is a composite of surface area and thickness, each reflecting distinct neurobiologic and genetic processes. The goal of this study was to investigate cerebral cortex (1) surface area, (2) surface geometric distortion, and (3) thickness in MTLE with hippocampal sclerosis (HS). Seventy patients with "sporadic" unilateral MTLE + HS and 40 healthy controls underwent T(1) -weighted MRI. Processing MR images using an automated cortical surface reconstruction method (FreeSurfer), we quantified cortical surface area, surface geometric distortion (metric distortion), and thickness at each vertex across the entire cortex. Differences between patients and controls were determined using generalized linear models. Separate linear regression models were employed to assess the relationship between cortical surface area and hippocampal volume as well as a series of important clinical features of the condition. We detected an asymmetric reduction in cortical surface area, predominantly in ipsilateral mesial and anterior temporal lobe subregions, of patients with MTLE + HS. Changes in surface geometric features were also evident and closely mirrored surface area patterns. In contrast, cortical thinning appeared dispersed across the cortex bilaterally. The regression models revealed that ipsilateral hippocampal volume was a significant predictor of temporal lobe surface area changes. Our findings indicate that contraction in surface area, rather than cortical thinning, explains ipsilateral mesial and anterior temporal lobe atrophy in patients with MTLE with HS. Furthermore, the alterations in surface geometry indicate folding abnormality involving the same regions. Cortical surface changes may represent sequelae of the disease or deviant cortical development.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Gianpiero L Cavalleri, Mary Fitzsimons, Norman Delanty, Paul Brennan, Sinead Maguire, Cathy Scanlon, Lena Palaniyappan, Colin P Doherty, Saud Alhusaini

Experts in our system

1
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35
 
2
Mary Fitzsimons
Royal College of Surgeons in Ireland
Total Publications: 7
 
3
Norman Delanty
Royal College of Surgeons in Ireland
Total Publications: 41
 
4
Paul Brennan
Dublin City University
Total Publications: 22
 
5
Cathy Scanlon
National University of Ireland Galway
Total Publications: 15
 
6
Colin P Doherty
Trinity College Dublin
Total Publications: 35
 
7
Saud Alhusaini
Royal College of Surgeons in Ireland
Total Publications: 10