Type

Journal Article

Authors

Catherine M Greene
Sally-Ann Cryan
Noel G McElvaney
Paul J McKiernan
Tidi Hassan

Subjects

Biochemistry

Topics
metabolism therapy humans lung diseases gene expression regulation micrornas genetics immunity innate drug effects antagonists inhibitors physiopathology inflammation gene targeting

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. (2012)

Abstract miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Catherine M Greene, Sally-Ann Cryan, Noel G McElvaney, Paul J McKiernan, Tidi Hassan

Experts in our system

1
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150
 
2
Sally-Ann Cryan
Royal College of Surgeons in Ireland
Total Publications: 70
 
3
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
4
Paul J McKiernan
Royal College of Surgeons in Ireland
Total Publications: 13
 
5
Tidi Hassan
Royal College of Surgeons in Ireland