Type

Journal Article

Authors

Gianpiero L Cavalleri
Norman Delanty
Sanjay M Sisodiya
Erin L Heinzen
Rodney A Radtke
Dalia Kasperavičiūtė
Gerard D O'Conner
Elijah Chaila
Chantal Depondt
Massimo Pandolfo
and 4 others

Subjects

Microbiology

Topics
biomarkers pharmacological phenytoin hla a 31 01 antigen polymorphism single nucleotide adverse effects humans hla a antigens carbamazepine drug hypersensitivity therapeutic use genetics genome wide association study triazines lamotrigine

Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (2012)

Abstract An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous adverse drug reactions (cADRs) attributed to lamotrigine and phenytoin. We recruited patients with lamotrigine-induced cADRs (n = 46) and patients with phenytoin-cADRs (n = 44) and the 1958 British birth cohort was used as a control (n = 1296). HLA-A*3101 was imputed from genome-wide association study data. We applied genome-wide association to study lamotrigine- and phenytoin-induced cADR, and total cADR cases combined. Neither HLA-A*3101 nor any other genetic marker significantly predicted lamotrigine- or phenytoin-induced cADRs. HLA-A*3101 does not appear to be a predictor for lamotrigine- and phenytoin-induced cADRs in Europeans. Our genome-wide association study results do not support the existence of a clinically relevant common variant for the development of lamotrigine- or phenytoin-induced cADRs. As a predictive marker, HLA-A*3101 appears to be specific for carbamazepine-induced cADRs.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Gianpiero L Cavalleri, Norman Delanty, Sanjay M Sisodiya, Erin L Heinzen, Rodney A Radtke, Dalia Kasperavičiūtė, Gerard D O'Conner, Elijah Chaila, Chantal Depondt, Massimo Pandolfo and 4 others

Experts in our system

1
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35
 
2
Norman Delanty
Royal College of Surgeons in Ireland
Total Publications: 41
 
3
Sanjay M Sisodiya
Royal College of Surgeons in Ireland
Total Publications: 13