Type

Journal Article

Authors

Mary Cannon
David R Cotter
Maurice Clancy
Matti O Huttunen
Antti Tanskanen
Mary C Clarke

Subjects

Psychiatry

Topics
epidemiology bipolar disorder statistics numerical data humans risk factors schizophrenia psychotic disorders family health psychology epilepsy complications genetics genetic predisposition to disease population groups finland

Evidence for shared susceptibility to epilepsy and psychosis: a population-based family study. (2011)

Abstract There is emerging evidence of an etiological overlap between a range of neurodevelopmental disorders, including schizophrenia and epilepsy. Here we investigate shared familial vulnerability to psychotic illness and epilepsy in a family-based study. The study population consisted of parents and their children born in Helsinki between 1947 and 1990. The Finnish Hospital Discharge Register was used to determine psychiatric and neurological outcomes in adulthood for all offspring. Parental history of psychosis and epilepsy was determined by linking the Hospital Discharge Register and the Finnish Population Register. Our total sample comprised 9653 families and 23,404 offspring. Individuals with epilepsy had a 5.5-fold increase in the risk of having a broadly defined psychotic disorder, an almost 8.5-fold increase in the risk of having schizophrenia, and a 6.3-fold increase in the risk of having bipolar disorder. There was strong evidence of clustering of the association between epilepsy and psychosis within families. Individuals with a parental history of epilepsy had a 2-fold increase in the risk of developing psychosis, compared with individuals without a parental history of epilepsy. Individuals with a parental history of psychosis had, reciprocally, a 2.7-fold increase in the risk of having a diagnosis of generalized epilepsy, compared with individuals without a parental history of psychosis. Post hoc analyses showed that these associations were not driven by the comorbidity of epilepsy and psychosis in the parents. These findings support recent evidence of overlapping etiological factors between epilepsy and schizophrenia, especially recent evidence of a genetic overlap between these disorders.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Mary Cannon, David R Cotter, Maurice Clancy, Matti O Huttunen, Antti Tanskanen, Mary C Clarke

Experts in our system

1
Mary Cannon
Royal College of Surgeons in Ireland
Total Publications: 90
 
2
David R Cotter
Royal College of Surgeons in Ireland
Total Publications: 56
 
3
Mary C Clarke
Royal College of Surgeons in Ireland
Total Publications: 78