Type

Journal Article

Authors

Emer P Reeves
Noel G McElvaney
Killian Hurley
David A Bergin

Subjects

Microbiology

Topics
therapeutic use immunity innate lung diseases drug effects alpha 1 antitrypsin humans pharmacology anti inflammatory agents non steroidal animals cell movement immunology alpha 1 antitrypsin deficiency complications neutrophils signal transduction drug therapy

Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent. (2011)

Abstract Alpha-1 antitrypsin (AAT) has long been thought of as an important anti-protease in the lung where it is known to decrease the destructive effects of major proteases such as neutrophil elastase. In recent years, the perception of this protein in this simple one dimensional capacity as an anti-protease has evolved and it is now recognised that AAT has significant anti-inflammatory properties affecting a wide range of inflammatory cells, leading to its potential therapeutic use in a number of important diseases. This present review aims to discuss the described anti-inflammatory actions of AAT in modulating key immune cell functions, delineate known signalling pathways and specifically to identify the models of disease in which AAT has been shown to be effective as a therapy.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Emer P Reeves, Noel G McElvaney, Killian Hurley, David A Bergin

Experts in our system

1
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
2
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
3
David A Bergin
Royal College of Surgeons in Ireland
Total Publications: 28