Type

Journal Article

Authors

Fergal J O'Brien
Garry P Duffy
Glenn R Dickson
Kazuhisa Bessho
Frank G Lyons
Grainne M Cunniffe
Caroline M Curtin

Subjects

Biochemistry

Topics
metabolism humans nanostructures animals chemistry rats cytology genetics transfection tissue scaffolds mesenchymal stromal cells collagen bone morphogenetic proteins osteogenesis cell line nanomedicine durapatite

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation. (2011)

Abstract The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Fergal J O'Brien, Garry P Duffy, Glenn R Dickson, Kazuhisa Bessho, Frank G Lyons, Grainne M Cunniffe, Caroline M Curtin

Experts in our system

1
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268
 
2
Garry P Duffy
Royal College of Surgeons in Ireland
Total Publications: 59
 
3
Glenn R Dickson
Royal College of Surgeons in Ireland
Total Publications: 7
 
4
Grainne M Cunniffe
Royal College of Surgeons in Ireland
Total Publications: 16
 
5
Caroline M Curtin
Royal College of Surgeons in Ireland
Total Publications: 22