Type

Journal Article

Authors

Gianpiero L Cavalleri
Mary Fitzsimons
Norman Delanty
Paul Brennan
Gabor Borgulya
Sinead Maguire
Lisa Ronan
Cathy Scanlon
Colin P Doherty
Saud Alhusaini

Subjects

Medicine & Nursing

Topics
young adult atrophy magnetic resonance imaging middle aged adult metabolism humans hippocampus sclerosis case control studies female pathology brain epilepsy temporal lobe male cross sectional studies

A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis. (2011)

Abstract Applying a cross-sectional design, we set out to further characterize the significance of extrahippocampal brain atrophy in a large sample of 'sporadic' mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). By evaluating the influence of epilepsy chronicity on structural atrophy, this work represents an important step towards the characterization of MRI-based volumetric measurements as genetic endophenotypes for this condition. Using an automated brain segmentation technique, MRI-based volume measurements of several brain regions were compared between 75 patients with 'sporadic' MTLE+HS and 50 healthy controls. Applying linear regression models, we examined the relationship between structural atrophy and important clinical features of MTLE+HS, including disease duration, lifetime number of partial and generalized seizures, and history of initial precipitating insults (IPIs). Significant volume loss was detected in ipsilateral hippocampus, amygdala, thalamus, and cerebral white matter (WM). In addition, contralateral hippocampal and bilateral cerebellar grey matter (GM) volume loss was observed in left MTLE+HS patients. Hippocampal, amygdalar, and cerebral WM volume loss correlated with duration of epilepsy. This correlation was stronger in patients with prior IPIs history. Further, cerebral WM, cerebellar GM, and contralateral hippocampal volume loss correlated with lifetime number of generalized seizures. Our findings confirm that multiple brain regions beyond the hippocampus are involved in the pathogenesis of MTLE+HS. IPIs are an important factor influencing the rate of regional atrophy but our results also support a role for processes related to epilepsy chronicity. The consequence of epilepsy chronicity on candidate brain regions has important implications on their application as genetic endophenotypes.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Gianpiero L Cavalleri, Mary Fitzsimons, Norman Delanty, Paul Brennan, Gabor Borgulya, Sinead Maguire, Lisa Ronan, Cathy Scanlon, Colin P Doherty, Saud Alhusaini

Experts in our system

1
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35
 
2
Mary Fitzsimons
Royal College of Surgeons in Ireland
Total Publications: 7
 
3
Norman Delanty
Royal College of Surgeons in Ireland
Total Publications: 41
 
4
Paul Brennan
Dublin City University
Total Publications: 22
 
5
Cathy Scanlon
National University of Ireland Galway
Total Publications: 15
 
6
Colin P Doherty
Trinity College Dublin
Total Publications: 35
 
7
Saud Alhusaini
Royal College of Surgeons in Ireland
Total Publications: 10