Type

Journal Article

Authors

Norman Delanty
Elijah Chaila
Saud Alhusaini
Mark McCormack
Gianpiero L Cavalleri

Subjects

Microbiology

Topics
polymorphism single nucleotide therapeutic use alleles pharmacogenetics adverse effects anticonvulsants humans epilepsy genetics classification biomarkers pharmacological genome wide association study drug therapy

Pharmacogenomics and epilepsy: the road ahead. (2011)

Abstract Epilepsy is one of the most common, serious neurological disorders, affecting an estimated 50 million people worldwide. The condition is typically treated using antiepileptic drugs of which there are 16 in widespread use. However, there are many different syndrome and seizure types within epilepsy and information guiding clinicians on the most effective drug and dose for individual patients is lacking. Further, all of the antiepileptic drugs have associated adverse reactions, some of which are severe and life-threatening. Here, we review the pharmacogenomic work to date in the context of these issues and comment on key aspects of study design that are required to speed up the identification of clinically relevant genetic factors.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Norman Delanty, Elijah Chaila, Saud Alhusaini, Mark McCormack, Gianpiero L Cavalleri

Experts in our system

1
Norman Delanty
Royal College of Surgeons in Ireland
Total Publications: 41
 
2
Saud Alhusaini
Royal College of Surgeons in Ireland
Total Publications: 10
 
3
Mark McCormack
Royal College of Surgeons in Ireland
 
4
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35