Type

Journal Article

Authors

Caoimhín G Concannon
Jochen H M Prehn
Deborah A McNamara
Elaine W Kay
Patrick G Johnston
Patrick Dicker
Robert J Cummins
Suzanne Hector
Susan Conlon
Niamh McCawley

Subjects

Microbiology

Topics
multivariate analysis male aged pathology humans middle aged metabolism proteasome endopeptidase complex prognosis immunohistochemistry colorectal neoplasms female tumor markers biological

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer. (2011)

Abstract Colorectal cancer is a leading cause of cancer-related deaths worldwide. Early diagnosis and treatment of colorectal cancer is the key to improving survival rates and as such a need exists to identify patients who may benefit from adjuvant chemotherapy. The dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in oncogenesis and cancer cell survival, and proteasome inhibitors are in clinical use for a number of malignancies including multiple myeloma. In our study, we examined the protein expression of several key components of the UPS in colorectal cancer using immunohistochemistry to determine expression levels of ubiquitinylated proteins and the proteasomal subunits, 20S core and Rpt4 in a cohort of 228 patients with colon cancer. Multivariate Cox analysis revealed that neither the intensity of either ubiquitinylated proteins or the 20S core was predictive in either Stage II or III colon cancer for disease free survival or overall survival. In contrast, in Stage II patients increased Rpt4 staining was significantly associated with disease free survival (Cox proportional hazard ratio 0.605; p = 0.0217). Our data suggest that Rpt4 is an independent prognostic variable for Stage II colorectal cancer and may aid in the decision of which patients undergo adjuvant chemotherapy.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Caoimhín G Concannon, Jochen H M Prehn, Deborah A McNamara, Elaine W Kay, Patrick G Johnston, Patrick Dicker, Robert J Cummins, Suzanne Hector, Susan Conlon, Niamh McCawley

Experts in our system

1
Caoimhín G Concannon
Royal College of Surgeons in Ireland
Total Publications: 46
 
2
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
3
Deborah A McNamara
Royal College of Surgeons in Ireland
Total Publications: 17
 
4
Elaine W Kay
Royal College of Surgeons in Ireland
Total Publications: 157
 
5
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
 
6
Robert Cummins
Royal College of Surgeons in Ireland
Total Publications: 22
 
7
Suzanne Hector
Royal College of Surgeons in Ireland
Total Publications: 13
 
8
Niamh McCawley
Royal College of Surgeons in Ireland
Total Publications: 9