Type

Journal Article

Authors

Leonie S Young
Arnold D K Hill
Marie McIlroy
Kilian Perrem
Achim Treumann
Elaine Kay
Patrick Fahy-Browne
Paul Tibbitts
Sinéad Cocchiglia
Jean McBryan
and 2 others

Subjects

Biochemistry

Topics
gene expression regulation neoplastic pathology colonic neoplasms carrier proteins humans physiology tert protein human ets2 protein human telomerase proto oncogene protein c ets 2 ruvbl2 protein human transcription genetic chemistry dna helicases genetics proteomics disease progression

RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer. (2011)

Abstract Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P<0.01, P=0.05 and P=0.03 respectively, n=170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Leonie S Young, Arnold D K Hill, Marie McIlroy, Kilian Perrem, Achim Treumann, Elaine Kay, Patrick Fahy-Browne, Paul Tibbitts, Sinéad Cocchiglia, Jean McBryan and 2 others

Experts in our system

1
Leonie S Young
Royal College of Surgeons in Ireland
Total Publications: 42
 
2
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
 
3
Marie McIlroy
Royal College of Surgeons in Ireland
 
4
Elaine W Kay
Royal College of Surgeons in Ireland
Total Publications: 157
 
5
Paul Tibbitts
Royal College of Surgeons in Ireland
Total Publications: 11
 
6
Sinéad Cocchiglia
Royal College of Surgeons in Ireland
Total Publications: 10
 
7
Jean McBryan
Royal College of Surgeons in Ireland
Total Publications: 10