Type

Journal Article

Authors

Noel G McElvaney
Michelle A Murray
David A Bergin
Emer P Reeves

Subjects

Microbiology

Topics
extracellular matrix pathology glycosaminoglycans physiopathology respiratory system humans physiology respiration disorders etiology cystic fibrosis chemistry immunology microbiology signal transduction peptide hydrolases complications metabolism

The involvement of glycosaminoglycans in airway disease associated with cystic fibrosis. (2011)

Abstract Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Noel G McElvaney, Michelle A Murray, David A Bergin, Emer P Reeves

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
David A Bergin
Royal College of Surgeons in Ireland
Total Publications: 28
 
3
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63