Type

Journal Article

Authors

H Humphreys
A D K Hill
M A Corrigan
C J Collins
S M McHugh

Subjects

Microbiology

Topics
surgical wound infection humans antibiotic prophylaxis treatment outcome randomized controlled trials as topic anti infective agents local therapeutic use prevention control

The role of topical antibiotics used as prophylaxis in surgical site infection prevention. (2011)

Abstract Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining 'topical' or 'local' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

H Humphreys, A D K Hill, M A Corrigan, C J Collins, S M McHugh

Experts in our system

1
Hilary Humphreys
Royal College of Surgeons in Ireland
Total Publications: 142
 
2
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
 
3
M A Corrigan
University College Cork
Total Publications: 21
 
4
Sheena M. McHugh
University College Cork
Total Publications: 52