Type

Journal Article

Authors

Emer P Reeves
Noel G McElvaney
Kerstin Pohl
Elaine Hayes

Subjects

Microbiology

Topics
respiratory burst pathology nadph oxidase neutrophils therapy humans neutrophil activation phagocytosis cell degranulation animals chemotaxis leukocyte cystic fibrosis immunology genetics microbiology apoptosis metabolism

The cystic fibrosis neutrophil: a specialized yet potentially defective cell. (2010)

Abstract Cystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite advances in our understanding of the molecular and cellular basis of CF, there remains a paradox of why recruited CF neutrophils fail to eradicate bacterial infections in the lung. This review describes mechanisms involved in neutrophil migration, microbial killing and apoptosis leading to inflammatory resolution. We discuss dysregulated neutrophil activity and consider genetic versus inflammatory neutrophil reprogramming in CF and ultimately pharmacological modulation of the CF neutrophil for therapeutic intervention.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Emer P Reeves, Noel G McElvaney, Kerstin Pohl, Elaine Hayes

Experts in our system

1
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
2
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
3
Kerstin Pohl
Royal College of Surgeons in Ireland
 
4
Elaine Hayes
Dublin City University
Total Publications: 5