Type

Journal Article

Authors

M Rehm
E Passante
C T Hellwig

Subjects

Biochemistry

Topics
physiology inhibitor of apoptosis proteins humans metabolism mitochondrial membranes proto oncogene proteins c bcl 2 animals receptors death domain apoptosis neoplasms chemistry cell membrane permeability alzheimer disease amino acid sequence diabetes mellitus pathology caspases

The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. (2010)

Abstract The regulation of apoptotic cell death, a terminal and fatal cell fate decision, has been intensely investigated and, due to its paramount implications for human health and disease, has sparked one of the most prolific and competitive research fields in biological and biomedical sciences of the past decades. Many key components of the molecular machinery processing and transducing apoptotic cell death signals have been described in great detail by now, dramatically advancing our understanding of how the network of apoptosis signaling proteins integrates and regulates cell death signals, and ultimately executes apoptosis. Building on the latest significant advances in deciphering apoptosis signal transduction as well as on the central original groundbreaking discoveries in cell death research, we here present an in-depth description of the current knowledge on the core molecular machinery of apoptotic signaling and how it is implicated in human physiology and pathophysiologies.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

M Rehm, E Passante, C T Hellwig

Experts in our system

1
Markus Rehm
Royal College of Surgeons in Ireland
Total Publications: 55
 
2
E Passante
Royal College of Surgeons in Ireland
Total Publications: 6
 
3
Christian T Hellwig
Royal College of Surgeons in Ireland
Total Publications: 11