Type

Journal Article

Authors

Jochen H M Prehn
Seán M Kilbride
Jakub Wenus
Heiko Duessmann
Heinrich J Huber

Subjects

Biochemistry

Topics
animals pathology models theoretical signal transduction mitochondria apoptosis metabolism humans

Mathematical modelling of the mitochondrial apoptosis pathway. (2010)

Abstract Mitochondria are pivotal for cellular bioenergetics, but are also a core component of the cell death machinery. Hypothesis-driven research approaches have greatly advanced our understanding of the role of mitochondria in cell death and cell survival, but traditionally focus on a single gene or specific signalling pathway at a time. Predictions originating from these approaches become limited when signalling pathways show increased complexity and invariably include redundancies, feedback loops, anisotropies or compartmentalisation. By introducing methods from theoretical chemistry, control theory, and biophysics, computational models have provided new quantitative insights into cell decision processes and have led to an increased understanding of the key regulatory principles of apoptosis. In this review, we describe the currently applied modelling approaches, discuss the suitability of different modelling techniques, and evaluate their contribution to the understanding of the mitochondrial apoptosis pathway. This article is part of a Special Issue entitled Mitochondria: the deadly organelle.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Jochen H M Prehn, Seán M Kilbride, Jakub Wenus, Heiko Duessmann, Heinrich J Huber

Experts in our system

1
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
2
Heiko Duessmann
Royal College of Surgeons in Ireland
Total Publications: 5
 
3
Heinrich J Huber
Royal College of Surgeons in Ireland
Total Publications: 39