Type

Journal Article

Authors

Jochen H M Prehn
Caoimhín G Concannon
Manus W Ward
Liam P Tuffy
David Davila
Petronela Weisova

Subjects

Biochemistry

Topics
enzymology genetics apoptosis animals metabolism neurons humans physiology amp activated protein kinases cell survival

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons. (2010)

Abstract 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate, in particular cell cycle progression and apoptosis activation. Here, we describe the diverse mechanisms of AMPK activation and the role of AMPK in the regulation of cellular energy balance. We summarize recent studies implicating AMPK activation in the regulation of neuronal survival and as a key player during ischemic stroke. We also suggest that AMPK activation may have dual functions in the regulation of neuronal survival: AMPK provides a protective effect during transient energy depletion as exemplified in a model of neuronal Ca(2+) overloading, and this effect is partially mediated by the activation of neuronal glucose transporter 3. Prolonged AMPK activation, on the contrary, can lead to neuronal apoptosis via the transcriptional activation of the proapoptotic Bcl-2 family member, bim. Molecular switches that determine the protective versus cell death-inducing effects of AMPK activation are discussed.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Jochen H M Prehn, Caoimhín G Concannon, Manus W Ward, Liam P Tuffy, David Davila, Petronela Weisova

Experts in our system

1
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
2
Caoimhín G Concannon
Royal College of Surgeons in Ireland
Total Publications: 46
 
3
Liam P Tuffy
Royal College of Surgeons in Ireland
Total Publications: 13
 
4
Petronela Weisova
Royal College of Surgeons in Ireland
Total Publications: 10