Journal Article


L Young
A D K Hill
D Collins



therapeutic use breast neoplasms humans pharmacology antibodies monoclonal humanized drug interactions antineoplastic combined chemotherapy protocols antibodies monoclonal female antineoplastic agents drug therapy trastuzumab administration dosage lapatinib quinazolines

Lapatinib: a competitor or companion to trastuzumab? (2009)

Abstract Trastuzumab (Herceptin), a monoclonal antibody against HER2 has established itself as the treatment paradigm of HER2-overexpressing breast cancer. Its success, however, has been tempered by its sequelae. In particular, most tumours become resistant to trastuzumab through a variety of mechanisms. Furthermore, there is both an increased incidence of cardiac dysfunction and a worrying pattern of CNS metastasis associated with trastuzumab. To manage these concerns, many new treatments targeting HER2 have been developed. Of these emerging therapies, the dual tyrosine kinase receptor inhibitor against EGFR and HER2, lapatinib (Tyverb/Tykerb) has shown the most promise to date. Encouraging early results in vitro have now been reproduced in phase II/III clinical trials, both as lapatinib monotherapy and synergistically with other established therapeutic regimes, including trastuzumab itself. Trial results suggest it may be of considerable benefit to patients with trastuzumab-resistant tumours and may play a role in the reduction of CNS relapses. In addition, lapatinib is well-tolerated and unlike trastuzumab, minimal cardiac dysfunction has been documented. A number of trials are underway to assess whether lapatinib will oust trastuzumab from its pole position in the management of HER2-positive breast cancer or whether their combination will prove to be superior to either therapy alone.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

L Young, A D K Hill, D Collins

Experts in our system

Leonie S Young
Royal College of Surgeons in Ireland
Total Publications: 42
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
Denis M Collins
Dublin City University
Total Publications: 26