Journal Article


Shane J O'Neill
Noel G McElvaney
Catherine M Greene
Garret Cullen
Ruth E MacRedmond
Emer Kelly


Medicine & Nursing

female blood pressure interleukin 10 physiopathology prognosis aged 80 and over diagnosis blood community acquired infections male interleukin 6 young adult aging physiology severity of illness index humans middle aged adult aged blood urea nitrogen respiratory mechanics adolescent pneumonia prospective studies

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia? (2009)

Abstract Community-acquired pneumonia (CAP) is a major cause of death in the elderly. The age-related increase in comorbid illnesses plays a part but the effect of aging on the immune response may be equally important. We aimed to evaluate patients with CAP for evidence of a muted response to infection in elderly patients admitted to hospital compared with a younger patient group. Patients with CAP admitted through the Emergency Department were recruited for this prospective observational study. Clinical data were collected at presentation. Severity of pneumonia was assessed using the British Thoracic Society confusion, urea nitrogen, respiratory rate, blood pressure (CURB) score, the Pneumonia Severity Index (PSI) and the systemic inflammatory response syndrome (SIRS) definition. IL-6 and IL-10 levels were measured within 24 h of admission. Eighty patients were included in the study, of whom 38 (48%) were female. The median age was 74 years (range 18-95). Patients greater than 65 years of age had a lower incidence of chest pain and a higher incidence of altered mental status on presentation. CURB score and PSI were higher in the older patients. SIRS showed similar frequencies in both groups. IL-6 and IL-10 levels were similar in young (< 65 years), older (> 65 years) and very elderly (> 80 years) patients. This finding was not altered by severity of pneumonia. Age does not diminish the severity of illness scores in patients with CAP. There was no blunting of the systemic cytokine response with advanced age in this study.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Shane J O'Neill, Noel G McElvaney, Catherine M Greene, Garret Cullen, Ruth E MacRedmond, Emer Kelly

Experts in our system

Shane J O'Neill
Royal College of Surgeons in Ireland
Total Publications: 84
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150