Type

Journal Article

Authors

Jochen H M Prehn
Suzanne Hector

Subjects

Biochemistry

Topics
animals inhibitor of apoptosis proteins bax protein human genetics apoptosis bcl 2 associated x protein apaf1 protein human proto oncogene proteins c bcl 2 birc5 protein human prognosis colorectal neoplasms bcl x protein tumor markers biological neoplasm proteins autophagy pathology apoptotic protease activating factor 1 xaf1 protein human microtubule associated proteins bcl2l1 protein human caspases intracellular signaling peptides and proteins humans physiology

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. (2008)

Abstract Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival. However drug resistance, both innate and acquired, remains an obstacle in the effective treatment of this disease. Apoptotic pathways are frequently altered in both tumor progression and drug resistance; therefore proteins associated with this pathway may have potential as prognostic biomarkers for this disease. Identification of clinical biomarkers that are able to identify patients who are more likely to respond to specific chemotherapy will lead to more personalized, effective, and less toxic therapy. This review focuses on the current status of apoptosis related proteins as biomarkers for colorectal cancer and discusses the possible application of systems approaches in this context.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Jochen H M Prehn, Suzanne Hector

Experts in our system

1
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
2
Suzanne Hector
Royal College of Surgeons in Ireland
Total Publications: 13