Type

Journal Article

Authors

Michael Gill
Kevin J Mitchell
Colm M P O'Tuathaigh
Gary Donohoe
Aiden P Corvin
John L Waddington

Subjects

Biochemistry

Topics
mutation genomics models genetic genetics genetic predisposition to disease humans phenotype schizophrenia

Functional genomics and schizophrenia: endophenotypes and mutant models. (2007)

Abstract This article summarizes the rationale, methods, and results of gene discovery programs in schizophrenia research and describes functional methods of investigating potential candidate genes. It focuses next on the most prominent current candidate genes and describes (1) evidence for their association with schizophrenia and research into the function of each gene; (2) investigation of the clinical phenotypes and endophenotypes associated with each gene, at the levels of psychopathologic, neurocognitive, electrophysiologic, neuroimaging, and neuropathologic findings; and (3) research into the ethologic, cognitive, social, and psychopharmacologic phenotype of mutants with targeted deletion of each gene. It examines gene-gene and gene-environment interactions. Finally, it looks at future directions for research.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Michael Gill, Kevin J Mitchell, Colm M P O'Tuathaigh, Gary Donohoe, Aiden P Corvin, John L Waddington

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 294
 
2
Kevin J Mitchell
Trinity College Dublin
Total Publications: 48
 
3
Colm M P O'Tuathaigh
University College Cork
Total Publications: 78
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 162
 
5
Aiden Corvin
Trinity College Dublin
Total Publications: 218
 
6
John L Waddington
Royal College of Surgeons in Ireland
Total Publications: 170