Journal Article


N G McElvaney
C C Taggart
N McGarry
S Weldon



chemistry immunology prevention control physiopathology metabolism secretory leukocyte peptidase inhibitor anti infective agents pulmonary disease chronic obstructive inflammation leukocyte elastase humans anti inflammatory agents physiology protease inhibitors cystic fibrosis

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses. (2007)

Abstract Chronic lung disease is one of the most common causes of death and disability worldwide. This group of diseases is characterized by a protease burden, an infective process and a dominant pro-inflammatory profile. While SLPI (secretory leucoprotease inhibitor) was initially identified as a serine protease inhibitor, it has since been shown that SLPI possesses other properties distinct from those associated with its antiprotease capabilities that play an important role in protecting the host from infection and injury. In the course of this review, we will highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

N G McElvaney, C C Taggart, N McGarry, S Weldon

Experts in our system

Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
Clifford C Taggart
Royal College of Surgeons in Ireland
Total Publications: 54
Sinéad Weldon
Royal College of Surgeons in Ireland
Total Publications: 9