Journal Article


D Taylor
R Parkesh
T Gunnlaugsson
F J O'Brien
T C Lee



pathology stress mechanical weight bearing osteoporosis compressive strength connective tissue tissue engineering biomechanics fractures stress models biological physiology humans fractures bone bone density etiology bone and bones injuries adaptation physiological bone remodeling

Microdamage and bone mechanobiology. (2006)

Abstract Mechanobiology is concerned with the relationships between mechanical forces and biological processes. Bone adapts to altered mechanical loading by modelling and remodelling. Microdamage is a stimulus for adaptation as shown by a sheep overload model. If microdamage accumulates it leads to fracture failure, notably in osteoporosis. Detection methods, based on chelating fluorochromes and radiopaque agents, will enable microdamage to be quantified and, along with bone mass, aid in fracture prediction and prevention. Mechanobiological principles can be utilised to create tissue engineered bone grafts in cases of bone loss due to trauma, malignancy or resorption.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

D Taylor, R Parkesh, T Gunnlaugsson, F J O'Brien, T C Lee

Experts in our system

David Taylor
Trinity College Dublin
Total Publications: 75
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 265
T Clive Lee
Royal College of Surgeons in Ireland
Total Publications: 76