Journal Article


Alice V Stanton
Jan A Staessen
Eoin O'Brien
Sean McClory
Patricia McCormack
Neil Atkins
Yan Li
Lutgarde Thijs
Eamon Dolan


Medicine & Nursing

middle aged mortality ireland aged cardiovascular diseases blood pressure hypertension complications diastole systole etiology models cardiovascular follow up studies adult humans predictive value of tests female arteries physiopathology male stroke proportional hazards models compliance epidemiology blood pressure monitoring ambulatory

Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. (2006)

Abstract We hypothesized that the dynamic relation between diastolic and systolic blood pressure over 24 hours provides a measure of arterial stiffness and might, therefore, predict cardiovascular mortality over and above pulse pressure. At baseline, while not on antihypertensive medication, 11 291 patients (mean age, 54.6 years; 5965 women) underwent ambulatory blood pressure monitoring. Using all of the blood pressure readings, we plotted diastolic against systolic blood pressure from each individual and calculated the regression slope. The ambulatory arterial stiffness index (AASI) was defined as 1 minus this regression slope. Over a median follow-up of 5.3 years, 566 cardiovascular deaths occurred, including 151 from stroke and 358 from cardiac disorders. Before and after adjustment for other cardiovascular risk factors, AASI and pulse pressure significantly predicted total cardiovascular mortality. AASI was a stronger predictor than pulse pressure for stroke (mutually adjusted relative hazard ratios for 1 SD increase, 1.21 versus 1.04; P=0.02 versus 0.66) with the opposite trend for cardiac mortality (relative hazard ratios, 1.03 versus 1.21; P=0.63 versus 0.002). In subjects with normal daytime ambulatory blood pressure (<135/<85 mm Hg), AASI was more predictive than pulse pressure of cardiovascular mortality (1.26 versus 0.96; P=0.04 versus 0.70) and of stroke mortality (1.81 versus 1.12; P=0.007 versus 0.58), whereas neither independently predicted cardiac mortality (1.11 versus 0.89; P=0.47 versus 0.40). AASI is a novel measure of arterial stiffness, which can be readily determined from ambulatory blood pressure recordings and which independently predicts cardiovascular mortality, even in normotensive subjects.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Alice V Stanton, Jan A Staessen, Eoin O'Brien, Sean McClory, Patricia McCormack, Neil Atkins, Yan Li, Lutgarde Thijs, Eamon Dolan

Experts in our system

Alice Stanton
Royal College of Surgeons in Ireland
Total Publications: 44
Jan A Staessen
University College Dublin
Total Publications: 11
Eoin O'Brien
University College Dublin
Total Publications: 75
N Atkins
University College Dublin
Total Publications: 12
Yan Li
University College Dublin
Total Publications: 6
Lutgarde Thijs
University College Dublin
Total Publications: 10
Eamon Dolan
IT Blanchardstown
Total Publications: 42