Journal Article


Denis C Shields
Patrick Dicker
John K O'Brien
Alun Evans
David T Croke
Daniel G Bradley
Aisling O'Halloran
Ciara Dolan



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Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population. (2005)

Abstract Selection pressures from pathogens impact on the worldwide geographic distribution of polymorphisms in certain pathogen-response-associated genes. Such gene-specific effects could lead to confounding by geographic disease associations. We wished to determine if such constraints impinge on the genetic structure of a population of Irish patients and whether variants associated with responses to pathogens showed greater stratification. The counties of origin of each subject's grandparents were used as the geographic variable. F(st), proportional to the extent of population structure, was low (mean F(st)=0.004 across 25 SNPs, range 0.001-0.008) and it was not significantly higher for pathogen response SNPs (F(st)=0.004) than for other SNPs (F(st)=0.003, P=0.21). Correspondence analysis revealed weak trends primarily in approximately northeast to southwest and secondarily in northwest to southeast directions. One-dimensional spatial autocorrelation analysis revealed a weak (Moran's I autocorrelation of -0.10) tendency for SNP frequencies to diverge with greater distance. Two-dimensional autocorrelation indicated a northeast to southwest gradient that was similar for both the pathogen response and other SNPs. The southeastern county, Wexford, showed a distinctive pattern, perhaps consistent with Anglo-Norman settlements. In conclusion, these results indicate that pathogen response SNPs do not exhibit significantly more population structure than other SNPs within this Caucasian population. This suggests that the specific population structure of particular genes may not typically be a cause of strong confounding in genetic studies where population structure is controlled.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Denis C Shields, Patrick Dicker, John K O'Brien, Alun Evans, David T Croke, Daniel G Bradley, Aisling O'Halloran, Ciara Dolan

Experts in our system

Denis C. Shields
University College Dublin
Total Publications: 123
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
Daniel Bradley
Trinity College Dublin
Total Publications: 84
Aisling O'Halloran
Trinity College Dublin
Total Publications: 34