Type

Journal Article

Authors

Denis C Shields
Desmond J Fitzgerald
Christopher P Cannon
Anthony Fitzgerald
Connie E Byrne

Subjects

Microbiology

Topics
sialoglycoproteins leukocyte count acute disease coronary thrombosis clinical trials as topic syndrome polymorphism genetic genetic variation humans genotype biological markers recurrence myocardial infarction interleukin 1 receptor antagonist protein immunology c reactive protein genetics angina unstable diagnosis blood fibrinogen interleukin 6 inflammation il1rn protein human risk factors

Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes. (2003)

Abstract Elevated white blood cell counts (WBC) in acute coronary syndromes (ACS) increase the risk of recurrent events, but it is not known if this is exacerbated by pro-inflammatory factors. We sought to identify whether pro-inflammatory genetic variants contributed to alterations in WBC and C-reactive protein (CRP) in an ACS population. WBC and genotype of interleukin 6 (IL-6 G-174C) and of interleukin-1 receptor antagonist (IL1RN intronic repeat polymorphism) were investigated in 732 Caucasian patients with ACS in the OPUS-TIMI-16 trial. Samples for measurement of WBC and inflammatory factors were taken at baseline, i.e. Within 72 hours of an acute myocardial infarction or an unstable angina event. An increased white blood cell count (WBC) was associated with an increased C-reactive protein (r = 0.23, p < 0.001) and there was also a positive correlation between levels of beta-fibrinogen and C-reactive protein (r = 0.42, p < 0.0001). IL1RN and IL6 genotypes had no significant impact upon WBC. The difference in median WBC between the two homozygote IL6 genotypes was 0.21/mm3 (95% CI = -0.41, 0.77), and -0.03/mm3 (95% CI = -0.55, 0.86) for IL1RN. Moreover, the composite endpoint was not significantly affected by an interaction between WBC and the IL1 (p = 0.61) or IL6 (p = 0.48) genotype. Cytokine pro-inflammatory genetic variants do not influence the increased inflammatory profile of ACS patients.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Denis C Shields, Desmond J Fitzgerald, Christopher P Cannon, Anthony Fitzgerald, Connie E Byrne

Experts in our system

1
Denis C. Shields
University College Dublin
Total Publications: 123
 
2
D J Fitzgerald
Royal College of Surgeons in Ireland
Total Publications: 101
 
3
Anthony P Fitzgerald
University College Cork
Total Publications: 78