Type

Journal Article

Authors

Clifford C Taggart
Shane J O'Neill
Noel G McElvaney
Catherine M Greene

Subjects

Biochemistry

Topics
nf kappa b pancreatic elastase membrane glycoproteins tlr2 protein human immunology proteins secretory leukocyte peptidase inhibitor slpi protein human metabolism u937 cells monocytes lipopolysaccharides receptors cell surface macrophages toll like receptor 2 proteinase inhibitory proteins secretory lipoteichoic acid physiology humans teichoic acids pharmacology toll like receptors oxidation reduction

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. (2004)

Abstract Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-kappaB activation. We examined its ability to inhibit NF-kappaB activation induced by lipoteichoic acid and investigated the effects of oxidation or complex formation with neutrophil elastase on SLPI's anti-inflammatory properties in U937 myelomonocytic cells and macrophages.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Clifford C Taggart, Shane J O'Neill, Noel G McElvaney, Catherine M Greene

Experts in our system

1
Clifford C Taggart
Royal College of Surgeons in Ireland
Total Publications: 54
 
2
Shane J O'Neill
Royal College of Surgeons in Ireland
Total Publications: 84
 
3
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
4
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150