Type

Journal Article

Authors

Shane O'Neill
Noel McElvaney
Paula Gallagher
Gregory Lowe
Clifford Taggart
Catherine Greene

Subjects

Biochemistry

Topics
receptors cell surface humans metabolism adult cytology proteins female immunology enzymology neutrophils community acquired infections slpi protein human male pneumonia pneumococcal epithelium middle aged aged leukocyte elastase proteinase inhibitory proteins secretory neutrophil infiltration alpha 1 antitrypsin antagonists inhibitors animals lung secretory leukocyte peptidase inhibitor

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia. (2002)

Abstract Protease-antiprotease balance in 17 patients with unilateral community-acquired pneumonia (CAP) was characterized (day 6+/-0.8). Levels and activities of alpha-1 antitrypsin (A1AT), secretory leucoprotease inhibitor (SLPI), and neutrophil elastase (NE) were quantified. Lobes were designated as infected or uninvolved according to the presence of an infiltrate on chest radiograph. NE levels in infected lobes were higher than those in uninvolved lobes, and NE levels were significantly elevated in both, compared with that in control lobes (n=18; P<.01). A1AT and SLPI levels were similar in infected and uninvolved lobes and were significantly elevated, compared with those in control lobes (P<.05 and P<.005, respectively). Anti-NE activity in infected lobes was less than that in control or uninvolved lobes (P<.05); values in the latter 2 were similar. Free NE was detected in 7 of the infected samples, indicating that anti-NE capacity is impaired. Both A1AT and SLPI were cleaved or complexed in infected lobes, and A1AT was oxidized in infected lobes. We conclude that mean elastase levels are increased and that mean anti-elastase capacity is decreased in pneumonic lobes.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Shane O'Neill, Noel McElvaney, Paula Gallagher, Gregory Lowe, Clifford Taggart, Catherine Greene

Experts in our system

1
Shane J O'Neill
Royal College of Surgeons in Ireland
Total Publications: 84
 
2
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
3
Clifford C Taggart
Royal College of Surgeons in Ireland
Total Publications: 54
 
4
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150