Type

Journal Article

Authors

Shane O'Neill
Noel McElvaney
Paula Gallagher
Clifford Taggart
Gregory Lowe
Catherine Greene

Subjects

Biochemistry

Topics
female antagonists inhibitors interleukin 10 immunology receptors interleukin 1 tumor necrosis factor alpha convertase receptors tumor necrosis factor adam proteins metalloendopeptidases receptors interleukin 6 tumor necrosis factor alpha community acquired infections male cell count interleukin 6 humans middle aged metabolism bronchoalveolar lavage fluid down regulation cytology pneumonia interleukin 1

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia. (2002)

Abstract Bronchoalveolar lavage fluid recovered from infected and uninvolved lungs of patients with community-acquired pneumonia (CAP; n=16) on day 6+/-0.8 was analyzed for cytokine, soluble receptor, and antagonist levels. The role of tumor necrosis factor (TNF)-alpha-converting enzyme (TACE) in the resolution of the local inflammatory response was investigated. TNF-alpha, interleukin (IL)-1beta, and IL-6 were elevated in the infected versus uninvolved lobe, whereas IL-10 was not. Epithelial lining fluid (ELF) cytokine levels correlated with intracellular cytokine expression. Levels of proTNF-alpha were reciprocally related to TNF-alpha ELF levels. Levels of soluble receptors, generated by TACE cleavage of membrane-bound precursors, were compartmentalized to infected ELF. TACE was down-regulated by internalization in cells from the site of infection. These data demonstrate that, in vivo during CAP, TACE has a role in regulating resolution of the local inflammatory response by modulating levels of pro- and counterinflammatory mediators.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Shane O'Neill, Noel McElvaney, Paula Gallagher, Clifford Taggart, Gregory Lowe, Catherine Greene

Experts in our system

1
Shane J O'Neill
Royal College of Surgeons in Ireland
Total Publications: 84
 
2
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
3
Clifford C Taggart
Royal College of Surgeons in Ireland
Total Publications: 54
 
4
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150