Type

Journal Article

Authors

Hanni Kiiski
Richard Reilly

Subjects

Psychiatry

Topics
patients next generation medical devices multiple sclerosis speed event related potential information processing density neuroscience

Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study (2010)

Abstract Background: The no-go P3a is a variant of the P300 event-related potential (ERP) that indexes speed of information processing and attention allocation. The aim of this study was to compare ERP findings with results from the paced auditory serial addition test (PASAT) and quantify latency, amplitude and topographical differences in P3a ERP components between multiple sclerosis (MS) patients and controls. Patients and Methods: Seventy-four subjects (20 relapsing remitting (RRMS) patients, 20 secondary progressive (SPMS) patients and 34 controls) completed a three-stimulus oddball paradigm (target, standard, nontarget). Subjects participated in separate visual and auditory tasks while data were recorded from 134 EEG channels. Latency differences were tested using an ANCOVA. Topographical differences were tested using statistical parametric mapping. Results: Visual P3a amplitude correlated with PASAT score in all MS patients over frontal and parietal areas. There were significant differences in latency, amplitude, and topography between MS patients and controls in the visual condition. RRMS and SPMS patients differed in visual P3a latency and amplitude at frontal and parietal scalp regions. In the auditory condition, there were latency differences between MS patients and controls only over the parietal region. Conclusion: The present results demonstrate that information processing speed and attention allocation are impaired in MS.
Collections Ireland -> Trinity College Dublin -> Administrative Staff Authors (Scholarly Publications)
Ireland -> Trinity College Dublin -> Administrative Staff Authors

Full list of authors on original publication

Hanni Kiiski, Richard Reilly

Experts in our system

1
Hanni Kiiski
Trinity College Dublin
Total Publications: 11
 
2
Richard Reilly
Trinity College Dublin
Total Publications: 183