Type

Journal Article

Authors

D J Fitzgerald
C E Byrne
C P Cannon
B Moran
D Kenny
C Muckian
P A O'Neill
A P Fitzgerald
D C Shields

Subjects

Medicine & Nursing

Topics
thrombosis chemically induced polymorphism genetic etiology therapeutic use myocardial revascularization glycoproteins humans reverse transcriptase polymerase chain reaction recurrence drug therapy risk assessment prevention control antagonists inhibitors genetics coronary disease myocardial infarction genotype treatment outcome blood stroke adverse effects mortality platelet glycoprotein gpiib iiia complex pyrrolidines alanine hemorrhage orbofiban

The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists. (2001)

Abstract Genetic variants are risk factors for coronary disease, but their role in recurrent events and in response to treatment is less clear. We genotyped genetic variants implicated in primary coronary disease in 924 Caucasians with acute coronary syndromes participating in the OPUS-TIMI16 trial of the GPIIb/IIIa antagonist orbofiban. These were the platelet glycoprotein (GP) receptors GPIIIa, GPIa, GPIbalpha; platelet ligands beta-fibrinogen and von Willebrand Factor (vWF); interleukins (IL) IL-1RN, and IL-6; adhesion proteins E-selectin and P-selectin; and metalloproteinase MMP-9. Cox modelling of all genetic variants demonstrated no significant impact on the composite endpoint (P = 0.88), which included myocardial infarction (MI), death, recurrent ischemia, urgent revascularisation and stroke, but a significant impact on recurrent myocardial infarction alone (chi(2) = 20.4, 10 df, P = 0.04). There was a significant interaction of the polymorphisms with orbofiban treatment influencing bleeding outcomes (P = 0.004). Thus, genetic polymorphisms may be associated with subsequent myocardial infarction, and may also be associated with treatment-associated bleeding among coronary patients.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

D J Fitzgerald, C E Byrne, C P Cannon, B Moran, D Kenny, C Muckian, P A O'Neill, A P Fitzgerald, D C Shields

Experts in our system

1
D J Fitzgerald
Royal College of Surgeons in Ireland
Total Publications: 101
 
2
Christopher Byrne
Royal College of Surgeons in Ireland
Total Publications: 13
 
3
Dermot Kenny
Royal College of Surgeons in Ireland
 
4
Anthony P Fitzgerald
University College Cork
Total Publications: 78
 
5
Denis C. Shields
University College Dublin
Total Publications: 123