Journal Article


Bernadette Earley
Dermot G. Morris
David A. Kenny
Michael G. Diskin
Sinead M. Waters
Daragh Matthews


Agriculture & Food Science

diet gene expression heifers beef energy deficit energy requirements negative energy balance short

The effects of short term dietary restriction on haematological responses and leukocyte gene expression of anovulatory and ovulatory beef heifers. (2014)

Abstract The study objective was to characterise the impact of negative energy balance (NEB) on immune-stress responsiveness in beef heifers. A short term (18-day) dietary restriction model was used. Dietary restriction (0.4 maintenance (Mn) energy requirements) induced abrupt onset of anoestrus in nine heifers (Restricted Anovulatory; RA) while nineteen heifers maintained oestrous cyclicity (Restricted Ovulatory; RO). In addition a control (C) group of 12 heifers received a higher level of feeding (1.2 Mn). Haematological related biomarkers of husbandry stress, leukocyte gene expression of seven cytokine genes and five immunological biomarkers were investigated. After 18 days of differential feeding of the heifers alterations in eosinophil and monocyte numbers and altered expression of CXCL8, IL2 and TNFα could be attributed to diet restriction. More specifically, changes in these five variables were found in heifers that became anovulatory (RA) and are therefore considered to be more sensitive biomarkers to an energy deficit.
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Full list of authors on original publication

Bernadette Earley, Dermot G. Morris, David A. Kenny, Michael G. Diskin, Sinead M. Waters, Daragh Matthews

Experts in our system

Bernadette Earley
Total Publications: 120
D.A. Kenny
Total Publications: 147
M G Diskin
Total Publications: 94
Sinead M. Waters
Total Publications: 99