Type

Journal Article

Authors

Colin Hill
R Paul Ross
Debebe Alemayehu
Mary C. Rea

Subjects

Microbiology

Topics
administration dosage drug resistance multiple bacterial probiotics humans bacteriophages bacteriocins therapeutic use gastrointestinal tract prevention control microbiology clostridium difficile drug therapy animals pathogenicity clinical trials as topic virology anti bacterial agents clostridium infections

Gut solutions to a gut problem: bacteriocins, probiotics and bacteriophage for control of Clostridium difficile infection. (2013)

Abstract Clostridium difficile infection (CDI) is a major cause of morbidity and mortality among hospitalized patients and imposes a considerable financial burden on health service providers in both Europe and the USA. The incidence of CDI has dramatically increased in recent years, partly due to the emergence of a number of hypervirulent strains. The most commonly documented risk factors associated with CDIs are antibiotic usage leading to alterations of the gut microbiota, age >65 years and long-term hospital stay. Since standard therapies for antibiotic-associated diarrhoea and CDI have limited efficacy, there is now an urgent need for alternative therapeutics. In this review, we outline the current state of play with regard to the potential of gut-derived bacteriocins, probiotics and phage to act as antimicrobial agents against CDI in the human gut.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Colin Hill, R Paul Ross, Debebe Alemayehu, Mary C. Rea

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Mary C. Rea
Teagasc
Total Publications: 68